Police said the shooting took place just after 11:50 a.m. on eastbound Interstate 290 near Cicero Avenue.
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Police said one male victim was transported to a hospital and pronounced dead. A Chicago Fire Department spokesperson confirmed one person was taken to Loretto Hospital.
Police said a female victim refused treatment on the scene and took herself to a hospital.
Chopper 7HD flew over the scene and captured a woman being consoled not far from a silver SUV that sustained several bullet holes.
Eastbound traffic was being diverted off the highway at Harlem Avenue, while troopers investigated. The roadway reopened just after 2 p.m.
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A.J. Johnson, who was heading inbound, checked in on his mother, whose house overlooks the Eisenhower. She told him she heard the gunshots.
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"I'm very, very hesitant to drive on the Eisenhower, especially when I pass Austin, I have to say. When I come to see her, or drive to my office on Michigan Avenue, I'm like, really kind of scared," Johnson said.
Police did not immediately provide any additional information about what led up to the shooting or on possible suspects.
Illinois State Police said so far this year, there have been 54 shootings on area roadways. That number is down from 84 at this time last year.
Anyone who witnessed the shooting or has any knowledge of it is asked to call Illinois State Police at 847-294-4400 or email ISP.CrimeTips@Illinois.gov. Witnesses can remain anonymous.
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