The shooting happened Saturday around 4:28 a.m. on the 8200-block of South Ashland Avenue in the Gresham neighborhood.
After the 32-year-old man shot, his vehicle struck a parked semi-truck, police said.
READ MORE | At least 27 shot, 3 killed in Easter weekend gun violence across city, Chicago police say
The victim was taken to a local hospital, where he later died.
Nobody is in custody and CPD Area 2 detectives are investigating.
INTERACTIVE SAFETY TRACKER | Track crime and safety in your neighborhood