The man was in an apartment in the 2000-block of East 72nd Place about 2 a.m. before the incident, according to CPD.
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That's when a male suspect came in through the back door and began arguing with the man before shooting him multiple times in the chest and fleeing the scene, Chicago police said.
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The man was pronounced dead at the apartment.
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No one was in custody later Thursday morning, and Area One detectives are investigating.
CPD said the victim and suspect did not know each other.