Police say two males got out of a car and shot the victims.
The teen boy was shot in the back and was transported to Mt. Sinai Hospital, where he was pronounced dead. The medical examiner later identified him as Rishawn Hendricks.
The teen girl was struck twice in the neck and transported to Stroger Hospital in good condition, police said.
No one has been arrested and police are investigating.
At least 9 juveniles have been shot in Chicago since Friday night.
Editorial note: A previous version of this story said the shooting happened in Brighton Park.