The 30-year-old man was driving eastbound in the 200-block of East 31st Street at about 10:16 p.m. when someone in a white sedan fired shots, police said.
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The man was transported to the University of Chicago Medical Center with multiple gunshot wounds, where he was pronounced dead, police said. Authorities have not released the man's identity.
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Area One detectives are investigating and no one is in custody.