Cicero spokesperson Ray Hanania said the man was hit about 4:30 a.m. at 33rd Place and Cicero Avenue.
The unidentified individual was taken to Mt. Sinai Hospital and pronounced deceased.
The driver who hit the man remained on the scene.
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A contractor-style van could be seen on the scene later Monday morning, with damage to its front end.
A pair of shoes and shopping cart were also in the road.
Cicero Avenue was shut down for an investigation after the incident.