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Parts of a neighborhood in Cicero were blocked off as officers combed through the area with search dogs.
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Police responded to reports of gunshots in the 1800 block of South 48th Court, near 19th Street, just before 7:45 p.m.
Officers found two women, 19 and 29 years old, who had been shot. Both victims were transported to Mt. Sinai Hospital, where they were pronounced dead.
A neighbor, America Pantoja, told ABC7 she heard multiple gunshots coming from inside a home along her block. Then, Pantoja said, she saw her daughter's friend come out of that home, crying.
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That's when multiple people, including children, ran out of the home and into Pantoja's house, she said.
Pantoja said a family member told her the alleged gunshots stemmed from an argument.
Police said the shooting appears to be a domestic-related isolated incident.
Police are investigating and seeking a person of interest.