The crash happened at 5:18 a.m. on Route 47 near Beith Road, authorities said.
The deceased driver of a 1996 Mazda pickup truck has been identified as 49-year-old Maple Park man, Juan Galvez.
Sheriff's deputies reviewed dash cam footage from the semi-truck and determined that Galvez did not stop at a stop sign while traveling eastbound on Beith Road before crashing into the semi, which was traveling southbound on Route 47.
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Both vehicles were severely burned after the pickup truck became pinned sideways underneath the semi-truck, police said. Galvez was pronounced dead at the scene.
The driver of the semi-truck was not injured and was released at the scene.
Aerial video from Chopper 7 showed the aftermath of the crash as crews continued to clear the scene Tuesday morning.
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Route 47 was reopened to traffic Tuesday afternoon, hours after the crash, as authorities continued to investigate and clear the scene.