The shooting happened in the 1700-block of North Dodge Avenue just before 10:30 p.m., Evanston police said.
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Several people were spotted in a car driving away from the scene and heading into neighboring Skokie, where they ditched their vehicle near the Skokie Swift train station, according to police.
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"We've got reports of multiple offenders who fled the location and fled on foot and possibly entered into a vehicle, which led us here to Dempster and the Skokie Swift," Evanston police Sgt. Ken Carter said.
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Police were searching the area around the Skokie Swift station Sunday morning, but so far nobody is in custody.
The victim has been identified as 21-year-old Stanley Abutler, according to the medical examiner.
Police said the shooting did not appear to be random.
Anyone with information is asked to call Evanston police at 847-866-5000 or text a tip to www.cityofevanston.org/government/departments/police/text-a-tip.