A car and a semitrailer were both traveling south on I-55 just after 1:20 a.m., near mile marker 252, when the car rear-ended the truck, which was stopped due to construction lane closures, according to ISP.
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The car's driver, who was the sole occupant of the vehicle, suffered life-threatening injuries and died, police said.
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No identifying information was immediately provided about the person killed.
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The southbound lanes of I-55 were closed between U.S. 52 and Route 59 for about five hours for the investigation.
All lanes reopened about 6:10 a.m., but the closure had already caused a roughly 2-mile backup.