State police responded just after 8:50 a.m. to westbound I-290 near Harlem Avenue for a crash involving a commercial motor vehicle.
One person was pronounced dead on the scene.
The two right lanes of westbound I-290 were closed near Harlem just before 9 a.m. and remained closed as of about 10:30 a.m.
Traffic was getting through in the left lane.
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Chopper7HD was over the scene, and a large number of items could be seen spilled out on the side of the highway.
What appeared to be a delivery van had crashed into a semitrailer.
This is a developing story; check back with ABC7 Chicago for updates.