The crash occurred early Tuesday morning near Fair Oaks, Indiana, Indiana State Police Sgt. Glen Fifield said on Twitter.
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The honey was spilled across all the lanes at the 219-mile marker, and traffic is being diverted at exit 220, Fifield said.
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Use U.S. 41 or SR 55 as alternate routes, as there appeared to be a 5-mile backup due to the incident.
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As of about 10:30 a.m., the left lane was open. The right lane remains closed.