Illinois State Police said preliminary information shows a pickup truck rear-ended a semitrailer just after 2:30 p.m. on eastbound I-88 near York Road in DuPage County. The two vehicles then caught fire, police said.
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The pickup truck driver was taken Loyola University Medical Center in Maywood in critical condition, the Oak Brook Fire Department said.
Another person was transported to Elmhurst Hospital in Elmhurst in stable condition.
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The semi driver was not injured.
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The lanes of traffic were temporarily shut down due to the crash and fire debris.
Traffic was moving slowly on the left shoulder, and motorists were asked to seek alternate routes.