State troopers responded to westbound Interstate 88, near York Road and Oak Brook, just after 8:15 a.m. for a reported crash involving at least two vehicles and an occupied school bus.
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Ten people were taken to local hospitals with non-life threatening injuries, police said. One child and two adults from the bus were taken to hospitals, the FBI said.
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The crash scene spanned about 200 yards, Oak Brook fire officials said.
The left lane of westbound I-88 near York Road was closed for an investigation about 8:20 a.m., with traffic getting by in the right lanes.
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Police did not immediately provide information about how the crash occurred.