The crash occurred at about 5:30 a.m. in the westbound lanes of I-80 between U.S. 30 and Gougar Road.
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Police injuries have been reported from the crash. All westbound lanes of I-80 were n shut down at the scene of the crash. The lanes have since reopened.
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The crash comes as cold weather Monday morning brought strong winds and a wintry mix to parts of the area.
Further details were not immediately available.