Deputies responded about 4 p.m. to the 300-block of Middletree Road for a domestic disturbance, a Will County Sheriff's Office spokesman said Monday.
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Someone had called 911 to report that his 21-year-old brother, later identified as Jabbar Muhammad of Joliet, was armed with a knife and threatening his grandfather, police said.
When deputies arrived they saw Muhammad brandishing a knife and threatening his grandfather, Eldred Wells, 70, of Joliet, according to police.
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Deputies tried to deescalate the situation, but Muhammad lunged at his grandfather and stabbed him in the neck, police said.
The deputies shot at Muhammad, while he continued to stab Wells, police said.
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Muhammad was shot and deputies provided aid to both men until East Joliet Fire crews arrived.
Wells was taken to a local hospital, where he later died, and Muhammad died on the scene.
The Will/Grundy Major Crimes Task Force will be investigating the incident.