A vehicle was driving west on the Kennedy, or Interstate 90, near Cumberland Avenue just before 1:45 a.m. when it broke through a construction closure and hit a parked construction truck, according to ISP.
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No one was inside the truck at the time of the crash, but the driver of the other vehicle died on the scene, police said.
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Part of the Kennedy at Cumberland was closed until about 7 a.m. for a crash investigation.
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No information was immediately provided about the person killed.