It happened just before 4 a.m. at the Louis Vuitton store at Old Orchard Mall.
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Police said a suspect flashed a gun at a mall security officer who was near the store. The officer was unarmed and ran away.
Police said another suspect then drove a car through the store's front door to break in. A few others got out and stole merchandise.
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No injuries were reported, and there is no word on how much was stolen.