The woman was in the pedestrian crossing near 1401 Shermer Road just before 6:20 p.m. when a northbound train hit her, Northbrook police said.
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The Northbrook Fire Department took the woman to Evanston Hospital, police said. Her condition was unknown as of Tuesday morning.
The Shermer Road railroad crossing was blocked until 8:15 p.m., and Milwaukee District North trains were delayed for the rest of the night.
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Metra police are investigating.
The circumstances surrounding the incident were not immediately clear.