Michigan City and LaPorte County police said the truck crashed sometime before 7 a.m. at U.S. 20 and S.R. 212 in Michigan City.
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Everything is shut down in all directions around the intersection after part of the truck's load spilled on the roadway, police said.
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There were no major injuries, and police did not have an estimate for when the intersection would be reopened.
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S.R. 212 was already shut down between U.S. 20 and U.S. 12 due to ongoing construction.