The crash occurred in the 6300-block of Illinois Route 83 just before 7 p.m. as a car with six teenagers inside collided with another car, police said.
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Police said three teens were ejected from the vehicle and six people were transported to hospitals.
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A 14-year-old was killed in the crash and has been identified to the Cook County Medical Examiner's Office as Madison Harrison. She attended Eisenhower High School in Blue Island.
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The cause of the crash is being investigated.