The crash happened just after 11 p.m. at the intersection of Harrison Street and Independence Boulevard in Homan Square, Chicago police said.
The Cook County Medical Examiner says a 16-year-old boy and a female, who's age hasn't been given, were killed.
Chicago police initially said a 14-year-old girl was killed in the crash.
Three other people were also injured in the crash, police said.
Police say the teen was in a vehicle that ran a red light and was hit by another car and then hit a pole.
No further information was immediately available.
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