Police said the shooting happened in the Austin neighborhood's 5600-block of West Division Street around 9:30 p.m.
A 53-year-old man was outside when someone he had been arguing with shot at him, police said.
The victim, shot in the head, was taken to Loyola Hospital, where he was pronounced dead.
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There is no one in custody, and Area Five detectives are investigating.
Police did not immediately provide further information about the shooting.
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