The first crash happened at about 4:15 a.m. on the outbound Bishop Ford Freeway, or Interstate 94, just south of 115th Street, Chicago police said.
One of the people involved in the crash got out of his vehicle and was hit and killed by another vehicle, police said.
That vehicle did not stop, police said.
The medical examiner identified Calvin Winfield, 48, as the pedestrian killed.
SEE ALSO: Several injured in multi-car crash on Dan Ryan Expressway: Illinois State Police
No one else was injured.
The freeway was shut down in the area for hours, but reopened just before 8:30 a.m. on Saturday.
Police are investigating.