Police said the crash happened in the 6600-block of North Caldwell Avenue just before 3:30 a.m.
A 21-year-old man was driving northbound on Caldwell Avenue when he lost control of his vehicle, striking a tree, police said.
Police said the man was transported to Lutheran General Hospital, where he was pronounced dead.
The Cook County Medical Examiner's Office identified him as Axel Llamas.
CPD's Major Accidents Unit is investigating.
Police did not immediately provide further information about the crash.