The crash happened at about 7 p.m. near West 60th Street and South State Street, near Englewood and Washington Park, according to Chicago police.
Police said three suspects were speeding in a stolen car on State Street onto oncoming traffic.
The offending vehicle then crashed into a car and a CTA bus at the intersection.
The driver of the car was taken to the hospital where they later died.
Ten victims, including the driver of CTA bus #59, were taken to area hospitals with non-life-threatening injuries, police said.
The three suspects were taken into custody and taken to the hospital with non-life threatening injuries.
Chicago police said they found four firearms in the stolen car.
Charges are pending.