The crash happened near West 60th Street and South State Street, near Englewood and Washington Park, Chicago Fire Department officials said.
Four of the 14 people injured were in critical condition, CFD officials said. One of those four people was very critical.
"According to preliminary information, a #59 bus was traveling southbound on State Street approaching 60th, when two autos were involved in a collision and then both auto struck the bus," CTA said in a statement.
One of the vehicles has major damage and was nearly cut in half.
At least two of the crash victims were brought to the University of Chicago Medical Center for treatment.
The exact cause of the initial crash was not immediately known.
ABC7 has reached out to Chicago police for more information.
This is a breaking news story. More information will be added as it become available.