The shooting happened in the 1300-block of West 72nd Street near Ada Street around 3:36 a.m., according to police.
An 18-year-old woman was sitting in a parked car when she was shot in the head, Chicago police said.
It was not immediately known if the woman was the intended target for the early morning crime.
She was taken to an area hospital in critical condition where she later died.
No one is in custody. CPD detectives are conducting a homicide investigation.
READ ALSO | 17-year-old boy shot in Humboldt Park, Chicago police say