The stabbing happened around 10:30 a.m. in the 3500 block of South Rhodes Avenue, Chicago police said.
The location of the crime scene is less than a block away U.S. Congressman Jonathan Jackson's office.
Chicago police said a 39-year-old man was standing near a sidewalk when an unknown offender walked up to him and stabbed him in the chest with a sharp object.
The victim was taken to a hospital, where he was later pronounced dead, CPD said. His identity was not yet known.
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No arrests have been made as Chicago police continue to investigate.
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