The fire happened at an apartment near East 46th Street and Woodlawn Avenue in the Kenwood neighborhood.
The Chicago Fire Department initially said six people were taken to hospitals.
The Cook County Medical Examiner's Officer later confirmed two female victims died in connection to the fire. Their ages and identities were not immediately known.
Officials told ABC7 one victim jumped from the building.
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There is no word yet on how the fire started.
This is a developing story; check back with ABC7 Chicago for updates.