Chicago fire crews arrived sometime before 5:20 a.m. at the building near West 119th Street and South Eggleston Avenue in the city's West Pullman neighborhood.
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The second floor was engulfed in flames when they got there.
The snow and frigid temperatures made it tough to get the fire under control.
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One person was taken to a hospital but remained stable, CFD said.
Video of the scene showed large flames and heavy snow.