The crash happened on Sunday at about 2:53 a.m. on the westbound lanes of I-290 were closed near Harlem Avenue, ISP said.
ISP said the crashed involved a Jeep and a Saturn car.
Police said a woman was ejected from their vehicle and died at the scene.
She was identified as Mona V. Sims, 55 of Bellwood, according to the Cook County Medical Examiner's Office.
A second person was taken to an area hospital with injuries.
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