Andy Orozco suffered multiple blunt force injuries in the four-vehicle crash, officials said.
Illinois State Police said a black Chevrolet truck, driven by a 42-year-old Carpentersville man, was traveling west in the eastbound lanes of Interstate 290 near Wolf Road in Hillside just after 4:15 a.m.
The truck crashed into a 2006 silver Mitsubishi Lancer, driven by Orozco, which was traveling east on I-290, police said.
The truck then hit a 2024 white Jeep Wagoneer, driven by a 60-year-old Oswego man, police said.
A 1987 red Mazda RX7, driven by a 24-year-old Broadview man, was also hit and crashed into a concrete barrier, police said.
The wrong-way driver was taken to a local hospital with life-threatening injuries.
Orozco died at a hospital.
The Oswego man was taken to a hospital with non-life threatening injuries, and the Broadview man was not injured, police said.
The crash affected traffic for hours Sunday.
Illinois State Police continue to investigate the incident.