The shooting took place in the 12000-block of South LaSalle Street.
Police said a man, between 20 and 25 years old, was inside a vehicle when a dark colored vehicle approached.
A suspect inside the dark-colored vehicle took out a gun and fired before fleeing the scene, police said.
SEE ALSO: Man, 66, killed in Chatham drive-by shooting, Chicago police say
The victim was shot in the head and transported to Advocate Christ Hospital, where he later died, police said.
A gun was recovered from the scene and no one is in custody, police said. Area 2 detectives are investigating.
INTERACTIVE SAFETY TRACKER Track crime and safety in your neighborhood