The shooting happened at about 12:36 a.m. at a home in the 1700 Block of E. 67th Street, police said.
Police said a woman, 23, was shot in the face and neck. She was taken to the hospital with critical injuries.
A man, 23, was shot in the chest and abdomen. He was rushed to the hospital where he died.
There is no one in custody and Area One Detectives are investigating.
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