The crash happened at about 3:29 a.m. on Thursday.
The northbound Mannheim Road entrance ramp onto IB Eisenhower was closed as crews worked to clear the scene.
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Crews were able to get the driver out of the truck just before 5:20 a.m.
IDOT said the driver was taken to the hospital with serious injuries.
Crews expect the closure to be in place for a couple of hours.
IDOT confirmed that overnight weather conditions were not a factor in the crash.
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