The crash happened at about 2:53 a.m. on the westbound lanes of I-290 were closed near Harlem Avenue, ISP said.
ISP said the crashed involved a Jeep and a Saturn car.
One person was ejected from their vehicle and died at the scene.
A second person was taken to an area hospital with injuries.
ISP did not provide further details on the victims.
All lanes reopened at 9:35 a.m., according to ISP.
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