The crash happened on the northbound lanes of Cicero Avenue at Southwest Highway.
Chopper 7 was over the scene about 6 a.m., showing multiple police units there.
It showed a black SUV lodged into the rear of a River Valley Metro bus.
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The bus was able to be moved around 6:30 a.m.
It is unknown the extent of the injuries and if any passengers were onboard the bus.
The crash caused some slowdowns in the area as police worked to clear the scene.