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Cicero and Chicago first responders went to the scene of the crash at West Roosevelt Road and Cicero Avenue in Lawndale just before 12:30 p.m.
Witnesses said a white car was chasing down a black car from Cicero when the black car crashed into two other vehicles at the border in Chicago.
That's when, witnesses said, multiple gunmen hopped out the white car and began firing.
"And then, they rolled over to the side of the street, and no sooner after that, a Bucha came, turned guys got out with guns. He just started lighting up the car. It's like, it's a war. That's what we're in. We're in a war," Louis Rainone, the owner of Roosevelt Gold Exchange.
A Cicero spokesperson said at least four people suffered gunshot wounds, and one of those victims died on the scene.
The Chicago Fire Department said three other people were injured in the incident.
Two people were transported in critical condition to Stroger Hospital.
Two others were taken to Mt. Sinai Hospital in serious condition. Another person was taken to Mt. Sinai Hospital in good condition.
A sixth person was transported to Loretto Hospital in good condition.
"I heard an accident. I heard a couple loud bangs. And when I came to the front of the store, I heard multiple gunshots. Then I heard more, and then I heard more," Rainone said. "They just went to that side of the car and just started shooting him up. I have cameras. I looked to see if everything was clear. The white car took off. Soon after, the police came, the ambulance, the fire truck. It's been closed down ever since. All the businesses are closed. It's just one thing after the other."
It happened on a street, some say, has become a pathway paved with ongoing tragedy.
"Somebody can't even walk to the drug store," Rainone said. "It's violence. It's on an, almost, everyday basis. It's becoming terrible."
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The intersection of Roosevelt and Cicero is temporarily closed while police investigate the shooting.
So far, no one is in custody.
Information about the victims' identities was not immediately available.