As of Friday, 162 people have been notified. Of those, 82 are central office positions and the other 80 are citywide positions.
The cuts come as CPS tries to close a budget deficit that exceeds $730 million.
Officials plan to unveil details of the district's proposed budget later this week.
Officials said the cuts are necessary as the district's budget grapples with billions in long term debt, aging buildings and underfunding from the state.
District officials stressed the cuts don't directly impact the classroom despite proposing to trim non-school based expenses by another $105-million this year.