The crash took place about 1:40 p.m. on westbound I-290 at Higgins Road, police said.
State police said there were four vehicles involved, and one person died on the scene.
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Police did not immediately provide any additional information about possible injuries.
Four lanes of traffic are currently closed for an investigation.
Chopper 7 was over the scene about 4 p.m., and there was a large traffic backup.
A van appeared to be wedged underneath a semi.
This is a developing story; check back with ABC7 Chicago for updates.