ISP said the crash happened on westbound Interstate 290, near Meacham Road in Itasca, just after 3 a.m.
The two-vehicle crash caused life-threatening injuries, ISP confirmed. Multiple people were hospitalized.
All westbound lanes were closed for hours at Meacham Road as police investigated. Lanes reopened just after 9 a.m.
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What led up to the crash was not immediately clear.
Authorities did not immediately provide further information.