The crash took place just after 1 p.m. on westbound I-80 west of Briggs Street, state police said.
The driver of the truck changed lanes and hit the car, before hitting the concrete median, police said.
The truck driver was ejected, and taken to a nearby hospital with injuries. The extent of the injuries was not immediately clear.
The other driver was not injured.
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Illinois State Police said on X, formerly known as Twitter, just before 9:45 p.m. that all lanes had reopened.