Police said the shooting happened in the Logan Square neighborhood around 2:45 a.m.
A 35-year-old man was inside his vehicle in the 1700-block of North Spaulding Avenue when he started arguing with someone, who was also in a vehicle, police said.
Police said the 35-year-old got out of his vehicle, and that's when the other person, a male of an unknown age, took out a gun and fired shots.
The victim, shot in the body, was taken to Stroger Hospital, where he was pronounced dead.
SEE ALSO | Man stabbed, critically injured during argument in Logan Square: Chicago police
The shooter fled the scene.
There is no one in custody, and Area Five detectives are investigating.
Police did not immediately provide further information about the shooting.
INTERACTIVE SAFETY TRACKER Track crime and safety in your neighborhood