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The stabbing happened early Sunday around 1:29 a.m. in the 100-block of East 70th Street in Park Manor.
A man, 47, was stabbed in the upper thigh. He was taken to the hospital in good condition.
A woman and a different man were also taken to the hospital with minor injuries. They are expected to be okay.
Chicago police said the victims and suspects all knew each other.
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Two people were taken into custody.
No other injuries were reported. CPD Area One detectives are investigating.
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