The mother awoke Friday to her smoke alarm blaring around 9 a.m., Niles fire officials said.
She, her daughter and their two dogs were able to get out of the building, located near Madison Street and Caldwell Avenue in Niles, but did suffer smoke inhalation.
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They were taken to Lutheran General Hospital to be treated. The mother is in fair condition, and her daughter is in good condition, fire officials said.
The home is uninhabitable after the blaze.
It's not clear how the fire started, fire officials said.