A vehicle driving south on Interstate 57 at 167th Street in Oak Forest just before 11 a.m. lost control, hit the right guard rail and rolled over, police said.
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The driver and sole occupant of the vehicle was pronounced dead on the scene, police said.
All southbound lanes of I-57 are shut down for a crash investigation.
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Police did not immediately identify the deceased driver or say what led up to the crash.
This is a developing story; check back with ABC7 Chicago for updates.