The crash involved two cars and a semi near the Target on 95th Street in Oak Lawn.
The westbound lanes of 95th were blocked at Keeler Avenue as crews worked to clean the scene.
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Chopper 7 was over the scene around 6:30 a.m., showing a car on its side in front of a semi. The second vehicle was seen behind the semi.
The driver of one of the vehicles was taken to a nearby hospital for non-life threatening injuries, and the crash remains under investigation.