The incident took place in the inbound lanes of I-55 near State Street at about 1:20 a.m., police said.
The car was riddled with bullets, but the driver was not wounded, police said. The shooting caused the driver to crash into a wall and the driver was transported to Northwestern Memorial Hospital with injuries from the crash, police said.
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Police shut down parts of I-55 as they investigate the crash, with traffic being diverted off at the Chinatown feeder ramp. The inbound Dan Ryan Expressway ramp to the inbound Stevenson was closed to traffic as well.
Shortly before 7:30 a.m., all lanes were reopened to traffic.
Meanwhile on Cicero Avenue near the Stevenson, Cicero was shut down for more than two hours following a three-car crash.
A white Toyota Tacoma pick-up truck had its roof sheared off and the truck's doors were also ripped off.
Debris from the wreck was scattered across the roadway as tow truck crews worked to clear the heavily damaged truck.
Two other sedans involved in the crash with at least one car's airbags deploying.
Chopper7 was over the crash when at least one person was loaded into an ambulance.
ABC7 has reached out to Chicago police to get an update on the drivers' conditions. but are still awaiting more details.