The company said it will keep its headquarters in Deerfield, where the company has been rooted for decades.
"As we renew our focus on our stores and customer experience, we have made the decision to exit our office space at the Old Post Office," a spokesperson said.
Walgreens will exit the building by January 2026.
"Our commitment to serving communities across the country begins in our pharmacies and retail locations, and this decision reflects our continued prioritization of those investments," a spokesperson said.
It is unknown if employees will be asked to relocate to the suburban location.
No other information was immediately available.